MIRD Pamphlet No. 29: MIRDy90-A 90Y Research Microsphere Dosimetry Tool (2024)

Marquis, H., Ramos, J. C. O., Carter, L. M., Zanzonico, P., Bolch, W. E., Laforest, R., & Kesner, A. L. (2024). MIRD Pamphlet No. 29: MIRDy90-A 90Y Research Microsphere Dosimetry Tool. Journal of Nuclear Medicine, 65(5), 794-802. https://doi.org/10.2967/jnumed.123.266743

Marquis, Harry ; Ramos, Juan C.Ocampo ; Carter, Lukas M. et al. / MIRD Pamphlet No. 29 : MIRDy90-A 90Y Research Microsphere Dosimetry Tool. In: Journal of Nuclear Medicine. 2024 ; Vol. 65, No. 5. pp. 794-802.

@article{e96cf8281e2b4bb19b8a2840f611125d,

title = "MIRD Pamphlet No. 29: MIRDy90-A 90Y Research Microsphere Dosimetry Tool",

abstract = "90Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration-approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based treatment planning. Several different mathematical models are used to calculate the patient-specific prescribed activity of 90Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, and MIRD dual compartment (partition). Under the auspices of the MIRDsoft initiative to develop community dosimetry software and tools, the body surface area, MIRD single-compartment, MIRD dual-compartment, and MIRD multicompartment models have been integrated into a MIRDy90 software worksheet. The worksheet was built in MS Excel to estimate and compare prescribed activities calculated via these respective models. The MIRDy90 software was validated against available tools for calculating 90Y prescribed activity. The results of MIRDy90 calculations were compared with those obtained from vendor and communitydeveloped tools, and the calculations agreed well. The MIRDy90 worksheet was developed to provide a vetted tool to better evaluate patient-specific prescribed activities calculated via different models, as well as model influences with respect to varying input parameters. MIRDy90 allows users to interact and visualize the results of various parameter combinations. Variables, equations, and calculations are described in the MIRDy90 documentation and articulated in the MIRDy90 worksheet. The worksheet is distributed as a free tool to build expertise within the medical physics community and create a vetted standard for model and variable management.",

keywords = "90Y-microspheres, MIRD dual-compartment dosimetry, partition model dosimetry, radioembolization, selective internal radiation therapy (SIRT)",

author = "Harry Marquis and Ramos, {Juan C.Ocampo} and Carter, {Lukas M.} and Pat Zanzonico and Bolch, {Wesley E.} and Richard Laforest and Kesner, {Adam L.}",

note = "Publisher Copyright: {\textcopyright} 2024 by the Society of Nuclear Medicine andMolecular Imaging.",

year = "2024",

doi = "10.2967/jnumed.123.266743",

language = "English",

volume = "65",

pages = "794--802",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

number = "5",

}

Marquis, H, Ramos, JCO, Carter, LM, Zanzonico, P, Bolch, WE, Laforest, R & Kesner, AL 2024, 'MIRD Pamphlet No. 29: MIRDy90-A 90Y Research Microsphere Dosimetry Tool', Journal of Nuclear Medicine, vol. 65, no. 5, pp. 794-802. https://doi.org/10.2967/jnumed.123.266743

MIRD Pamphlet No. 29: MIRDy90-A 90Y Research Microsphere Dosimetry Tool. / Marquis, Harry; Ramos, Juan C.Ocampo; Carter, Lukas M. et al.
In: Journal of Nuclear Medicine, Vol. 65, No. 5, 2024, p. 794-802.

Research output: Contribution to journal › Article › peer-review

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T1 - MIRD Pamphlet No. 29

T2 - MIRDy90-A 90Y Research Microsphere Dosimetry Tool

AU - Marquis, Harry

AU - Ramos, Juan C.Ocampo

AU - Carter, Lukas M.

AU - Zanzonico, Pat

AU - Bolch, Wesley E.

AU - Laforest, Richard

AU - Kesner, Adam L.

N1 - Publisher Copyright:© 2024 by the Society of Nuclear Medicine andMolecular Imaging.

PY - 2024

Y1 - 2024

N2 - 90Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration-approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based treatment planning. Several different mathematical models are used to calculate the patient-specific prescribed activity of 90Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, and MIRD dual compartment (partition). Under the auspices of the MIRDsoft initiative to develop community dosimetry software and tools, the body surface area, MIRD single-compartment, MIRD dual-compartment, and MIRD multicompartment models have been integrated into a MIRDy90 software worksheet. The worksheet was built in MS Excel to estimate and compare prescribed activities calculated via these respective models. The MIRDy90 software was validated against available tools for calculating 90Y prescribed activity. The results of MIRDy90 calculations were compared with those obtained from vendor and communitydeveloped tools, and the calculations agreed well. The MIRDy90 worksheet was developed to provide a vetted tool to better evaluate patient-specific prescribed activities calculated via different models, as well as model influences with respect to varying input parameters. MIRDy90 allows users to interact and visualize the results of various parameter combinations. Variables, equations, and calculations are described in the MIRDy90 documentation and articulated in the MIRDy90 worksheet. The worksheet is distributed as a free tool to build expertise within the medical physics community and create a vetted standard for model and variable management.

AB - 90Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration-approved unsealed radionuclide brachytherapy devices to incorporate dosimetry-based treatment planning. Several different mathematical models are used to calculate the patient-specific prescribed activity of 90Y, namely, body surface area (SIR-Spheres only), MIRD single compartment, and MIRD dual compartment (partition). Under the auspices of the MIRDsoft initiative to develop community dosimetry software and tools, the body surface area, MIRD single-compartment, MIRD dual-compartment, and MIRD multicompartment models have been integrated into a MIRDy90 software worksheet. The worksheet was built in MS Excel to estimate and compare prescribed activities calculated via these respective models. The MIRDy90 software was validated against available tools for calculating 90Y prescribed activity. The results of MIRDy90 calculations were compared with those obtained from vendor and communitydeveloped tools, and the calculations agreed well. The MIRDy90 worksheet was developed to provide a vetted tool to better evaluate patient-specific prescribed activities calculated via different models, as well as model influences with respect to varying input parameters. MIRDy90 allows users to interact and visualize the results of various parameter combinations. Variables, equations, and calculations are described in the MIRDy90 documentation and articulated in the MIRDy90 worksheet. The worksheet is distributed as a free tool to build expertise within the medical physics community and create a vetted standard for model and variable management.

KW - 90Y-microspheres

KW - MIRD dual-compartment dosimetry

KW - partition model dosimetry

KW - radioembolization

KW - selective internal radiation therapy (SIRT)

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DO - 10.2967/jnumed.123.266743

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JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

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Marquis H, Ramos JCO, Carter LM, Zanzonico P, Bolch WE, Laforest R et al. MIRD Pamphlet No. 29: MIRDy90-A 90Y Research Microsphere Dosimetry Tool. Journal of Nuclear Medicine. 2024;65(5):794-802. doi: 10.2967/jnumed.123.266743